Business Type:Manufacturer
Country/Region:China
Ddu Verified
HOT Rank
6/10
Xi'an Sengmei Biological Technology Co., Ltd
We are professional supplier of animal and plant extracts.
Business Type:Manufacturer
Country/Region:China
Ddu Verified
HOT Rank
6/10
Introduction
Name: Reserpine
Cas No.: 50-55-5
Apperance: White fine powder
Purity: 8%,20%,40%,98%,4:1, 5:1 ,10:1
Molecular weight:608.68
Molecular formula: C33H40N2O9
Reserpine
was blocked by adrenergic neurons of antihypertensive drugs.This
product is the depletion of peripheral sympathetic nerve endings of
adrenaline, heart, brain and other tissues of catecholamines and 5 - HT
to anti-high blood pressure, slow heart rate and inhibition of the
central nervous system. Antihypertensive effect primarily by reducing
cardiac output and reduced peripheral resistance, part of the
cardiovascular reflex inhibition to achieve.Reserpine acts on
hypothalamic area produce sedation, but no cause drowsiness and
anesthetic effects, does not change the sleep EEG, can ease the anxiety
of patients with hypertension, tension and headaches.Experimental animal
for less than the clinical dose of reserpine, which appears miosis,
eyelid wrinkles and sagging, hypothermia, gastrointestinal symptoms such
as the acceleration of activity.
Function
Reserpine can lower blood pressure and heart rate, the role of slow, moderate and long-lasting stability and the role of the central nervous system, is a good sedative. The treatment of hypertensive patients using reserpine patch topical Lee, Shen buck stickers, hanging pressure attached to external use Chinese medicine posted combined to strengthen the blood pressure lowering effect.
Application
Sepcification
Items | Requirements | Results | |
Description | |||
Appearance | A off white crystalline powder, odor, apricot smell, tasteless | Conforms | |
Solubility | freely soluble in chloroform, sparingly soluble in acetone, and practically insoluble in water, methanol, ethanol or ether. | Conforms
| |
Specific optical rotation | -115~-131° | -128.4° | |
Identification | |||
Color reaction | A yellow color is produced, 5 minutes into the blue | Conforms | |
Color reaction | A rose red color is produced after 2 minutes | ||
Color reaction | A blue color is produced | Conforms | |
IR | Infrared absorption spectra of test and standard(or infrared reference spectra No. 195) are concordant | Conforms
| |
Tests | |||
Oxidation products | According to the UV Visible spectrophotometry, the 0.2mg/ml sample acetic acid solution absorbance was measured at a wavelength of 338nm not more than 0.10 | Conforms | |
Related Substances (HPLC) | Total Impurities ≤1.5% | 1.46% | |
Loss on drying | ≤0.5% | 0.31% | |
Residue on ignition | ≤ 0.15% | 0.09% | |
Assay(On dried basis) | 98.0% ~102.0%(HPLC) | 99.2% |