Xi'an Sengmei Biological Technology Co., Ltd

Name: Tianeptine Hemisulfate Monohydrate

Other names: Tianeptine Sulfate (Sulphate)

Chemical Name:

7-[(3-Chloro-6,11-dihydro-6-methyl-5,5-dioxidodibenzo[c,f][1,2]thiazepin-11-yl)amino] heptanoic acid hemisulfate monohydrate

CAS 1224690-84-9

Molecular Formula:  C₂₁H₂₅ClN₂O₄S •H₂O.H₂-(1/2)O₄S;

Molecular Weight: 504.00

PURITY: 99% min

Synonyms:Heptanoic acid, 7-((3-chloro-6,11-dihydro-6-methyl-5,5-dioxidodibenzo(c,f)(1,2)thiazepin-11-yl)amino)-, sulfate, hydrate (2:1:2), Tianeptine hemisulfate monohydrate 7-[(3-chloro-6-methyl-5,5-dioxo-11H-benzo[c][2,1]benzothiazepin-11-yl)amino]heptanoic acid hemisulfate monohydrate

Technical Information:

Application: Improved salt of Tianeptine, used in laboratory research related to major depressive disorder (MDD), also studied for effects on asthma and irritable bowel syndrome (IBS).

Appearance: White crystal powder

Solubility: Soluble In Dimethylformamide, insoluble in water and dichloromethane

Package: aluminium foil bag, carton box/fiber drum

There are no official precautions to be observed for Tianeptine Sulfate. However, due to its similarity to Tianeptine Sodium, it’s strongly advised to follow the same precautions for Tianeptine Sodium.

Storage / Stability: Unlike Tianeptine Sodium, the Sulfate form is not hygroscopic or light sensitive. However, as with most chemicals, storage should be within an airtight container, away from direct sunlight.

Tianeptine Sulfate (Sulphate) or Tianeptine Hemisulfate Monohydrate is modern pseudo-analogue of the famous Tianeptine Sodium. Tianeptine Sulfate was first mentioned in October 2009 with US patent number 8198268 B2 – pioneered by Hector Guzman at Janssen Biotech inc. This patent describes, in detail, “a novel sulfate salt of tianeptine with improved properties, more particularly tianeptine hemisulfate monohydrate”

Stability – Another major difference is the solubility and stability, with Tianeptine Sulfate described as being much less soluble, subsequently being much less hygroscopic than Tianeptine Sodium. This interesting property has meant that the relative stability of Tianeptine Sulfate in normal conditions is better, with less light sensitivity and an improved general physical stability.

Duration – Tianeptine Sulfate is thought to be absorbed and excreted and a much slower rate than Tianeptine Sodium – however, this information is based on hypothesized patent information and anecdotal user reports. This means that theoretically, if approved, Tianeptine Sulfate would require a less frequent dosing regime of maybe 1 dose per day, instead of the 3 times a day indicated for Tianeptine Sodium